• Intracytoplasmic sperm injection, or ICSI for short, is a procedure where your partner’s sperm is injected directly into your egg(s) for fertilization with IVF. You may have questions about using ICSI with IVF for male infertility and we are here to help. Here are some answers to common questions about ICSI.


  • Naturally, the ejaculated sperm swim through the uterus into the fallopian tubes, one of which will contain the egg ovulated that month. One of the sperm will pass through the different layers that protect the egg to fertilize it, and thus produce the zygote, which ends up forming the embryo.

    Intracytoplasmic sperm injection, better known as ICSI, is an assisted reproduction technique that involves the direct insertion of a sperm into the ovule to facilitate fertilization.


  • Men with a low sperm count, sperm motility problems or poor sperm morphology.
  • Other factors: repeated failure after several cycles of IVF and AI, low number of eggs after pick-up, etc.
  • History of fertilization failure.
  • Men who have had a vasectomy.
  • Assisted reproduction treatments in which a Preimplantation Genetic Test (PGT) is performed.
  • Infectious diseases or infertility caused by immune factors.
  • Cases of particularly valuable semen samples due to their limited quantity, as the ICSI technique optimizes their use:
  • 1. Men undergoing radio or chemotherapy treatment.
  • 2. Patients with difficulty achieving normal ejaculation, as in retrograde ejaculation.
  • 3. Men with no sperm in the ejaculate, in which case sperm can be obtained through testicular biopsy.